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Documentation of gender-variant roles dates back to 1200 BCE in Egypt.

Activists like Marsha P. Johnson and Sylvia Rivera , who founded Street Transvestite Action Revolutionaries (STAR), were essential to the early movement's backbone.

Pivotal moments of resistance against police harassment were led by trans people and drag queens, including the Cooper Donuts Riot (1959), the Compton’s Cafeteria Riot (1966), and the Stonewall Riots (1969).