: Binding to Type I (ALK3/ALK6) and Type II (BMPR2) receptors triggers the phosphorylation of R-Smads (Smad1/5/8) , which complex with Smad4 and move into the nucleus to regulate gene expression.
BMP4 is essential from the earliest stages of life, where its loss often leads to embryonic lethality. : Binding to Type I (ALK3/ALK6) and Type
Beyond development, BMP4 is a major player in adult metabolism and disease. : Binding to Type I (ALK3/ALK6) and Type