Ensure Legacy Components (DirectPlay) are enabled in Windows Features.
Change your display resolution or check the Rocksmith.ini file for correct settings. Rocksmith 2014 Remastered [FitGirl Repack]
Set your playback device to 16-bit, 48000Hz (DVD Quality) in Windows Sound Settings. Ensure Legacy Components (DirectPlay) are enabled in Windows
You must own the "Cherub Rock" DLC (or have the ID file) as it serves as the base for most CDLC. Rocksmith 2014 Remastered [FitGirl Repack]
If using a standard 1/4" to USB adapter, you will likely need the "NoCableLauncher" or "RS_ASIO" mod.