[s5e22] What A Difference A Day Makes May 2026

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances.

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation. [S5E22] What a Difference a Day Makes

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to. : Creator Shonda Rhimes noted that Denny's appearance

In , the Season 5, Episode 22 milestone titled " What a Difference a Day Makes " is a landmark 100th episode that originally aired on May 7, 2009. It is widely celebrated for its emotional depth, shifting from a planned grand wedding for Meredith and Derek to a poignant ceremony for Izzie Stevens and Alex Karev. The Unexpected Wedding In , the Season 5, Episode 22 milestone

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex.

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party.