Structure and function of otoferlin, a synaptic protein of ... - PMC
Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power tm,cc,jp
ions are bound per domain, with specific significance for the . Structure and function of otoferlin, a synaptic protein of
This guide focuses on the molecular mechanism of otoferlin-mediated vesicle docking and Ca 2+raised to the 2 plus power sensing in inner hair cells (IHCs). Role: Otoferlin acts as a key Ca 2+raised to the 2 plus power sensor for synaptic vesicle fusion in auditory IHCs. Structure and function of otoferlin